Uric Acid Level As A Risk Factor For Cardiovascular And All

Content

• Uric Acid Key Terms
• Decrease The Pain Of An Acute Attack
• Related Health Topics
• Treatment And Prevention

Having been born with a rare condition that causes high blood uric acid levels. People with Kelley-Seegmiller syndrome or Lesch-Nyhan syndrome have a partial or complete deficiency in an enzyme that helps to control uric acid levels. The buildup of uric acid that led to your gout attack can still harm your joints. The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe.

In women, use of combined oral contraceptive pills is significantly associated with lower serum uric acid. Following Le Chatelier's principle, lowering the blood concentration of uric acid may permit any existing crystals of uric acid to be gradually dissolved into the blood, whence the dissolved uric acid can be excreted. Maintaining a lower blood concentration of uric acid similarly should reduce the formation of new crystals.

Uric Acid Key Terms

Saito M, Ishimitsu T, Minami J, Ono H, Ohrui M, Matsuoka H. Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors. UA increase is observed in individuals with insulin resistance, probably because hyperisulinemia would cause lower renal UA excretion . Additionally, insulin could indirectly act on UA, since there is an association between hyperinsulinemia and hypertriglyceridemia. Fruit and vegetables, in addition to flavonoids, can contain other nutrients that can affect the plasma total antioxidant capacity .

Are blueberries bad for gout?

Meat: Though no longer part of a common diet in the United States, organ meats, such as liver, sweetbreads, and brains, are most dangerous for those with gout. High purine content: Bacon, turkey, veal, venison. Medium purine content: Beef, chicken, duck, ham, pork.

A lifelong urate-lowering therapy may be needed, with medications that prevent gout flares and ultimately dissolve crystals that are already in your body. If untreated, high uric acid levels may eventually lead to permanent bone, joint and tissue damage, kidney disease and heart disease. Research has also shown a link between high uric acid levels and type 2 diabetes, high blood pressure, and fatty liver disease. By inducing oxidative stress in both hepatocytes and pancreatic β, hyperuricemia can result in the development of insulin resistance and growth inhibition, which is associated with ectopic lipid deposition in the liver .

Decrease The Pain Of An Acute Attack

Hyperuricemia may also contribute to the metastasis of some cancers, but the precise mechanism still needs further exploration. We also suggest a new target that may integrate inflammation, oxidative stress, and cell cycle arrest, which have been largely neglected, but are known to be responsive to drug treatment. Based on preliminary clinical evidence, we suggest that drugs that lower serum uric acid might be useful to slow or delay the progression of cancer development.

These agents reliably decrease the inflammation and pain of gout. However, patients with ulcers, hypertension, coronary disease, and fluid retention must be careful with these agents, even for the short courses (usually 3-7 days) needed to resolve a gout attack. The doses of non-steroidal anti-inflammatory agents needed to resolve a gout attack are on the higher side, since full anti-inflammatory effect is needed. Over-the-counter dosage levels, for example, ibuprofen at 200mg, two tabs three times a day, are often insufficient.

Drinking plenty of water to remain well-hydrated can be beneficial in preventing gout attacks. Although the uric acid test cannot definitively diagnose gout, a test for monosodium urate in synovial fluid can. Aspirin and other salicylates have varying effects on uric acid. At low aspirin levels , aspirin can increase blood uric acid. On the other hand, in high doses , aspirin actually lowers the concentration of uric acid. In addition, you may need this test if you are undergoing chemotherapy or radiation therapy for cancer.

However, with the application of dozens of anticancer or auxiliary anticancer drugs for clinical use, an increasing number of patients become therapeutically resistant. Considering that long-term, costly research is required to develop new drugs, drug repurpose is gradually becoming a novel strategy to treat cancer. The existing drugs like statin and aspirin, which are used to treat cardiovascular diseases, have now received a lot of attention for cancer therapy . Because we now know the potential role of uric acid in cancer initiation and progression, there may also be uric acid-lowering drugs, which have the potential for treating cancer.

While hyperuricemia itself is not a disease—and in some cases causes no symptoms or problems—a prolonged state of this condition may lead to the development of uric acid crystals, which can be problematic. The most important thing is to work with your doctor to find out what’s causing your high uric acid levels and to treat any underlying conditions. If your levels are persistently high, your doctor may prescribe uric acid-lowering medication, such as non-steroidal anti-inflammatory drugs, allopurinol, febuxostat, probenecid, sulfinpyrazone, or benzbromarone . People with down syndrome consistently have higher blood uric acid levels . People with some rare genetic disorders (Lesch-Nyhan syndrome, Kelley-Seegmiller syndrome) have elevated uric acid levels, due to mutations in the HPRT gene . Other mammals have the ability to further break down uric acid, but humans have lost it.

A population-based prospective cohort study was performed of 1423 middle-aged Finnish men initially without cardiovascular disease, cancer, or diabetes. The main outcome measure was death from cardiovascular disease and any cause. This site is a valuable resource on the spectrum of arthritic disorders. As with Rilonacept above, this agent may have a future role in the acute treatment and relatively short-term prevention of gout, and may have a longer-term role in selected patients with problems with multiple other options. Fortunately, present medications are successful in the vast majority of gout patients. But some patients cannot tolerate our present arsenal of gout medications.

Complications Of Gout

Future work will likely concentrate on the utility of manipulating UA levels in attempts to modify disease. In recent years, much attention has been paid to the role of uric acid in disease modification. It has been hypothesized that uric acid reduces oxidative stress on neurons. This may have a significant bearing on therapeutic management of disease, as many neurological disorders are believed to result from oxidative stress. As a potentially modifiable risk factor, the prospect for uric acid and its derivatives to play a role in disease modification or prevention has great potential.