How To Reduce Uric Acid

Content

• Search Health Library
• Baseline Characteristics And Hyperuricemia
• Uric Acid Production
• Cancer Treatment
• Symptoms Of Gout

More research is needed to understand the connection between the above medical conditions and hyperuricemia. Ask your healthcare provider if you should avoid any foods, beverages, or medicines before the test. Be sure your provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illegal drugs you may use. Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Even as you sleep, your blood flows, your brain fires away, and your gut digests that late-night snack.

In addition to its association with the development of digestive cancer, SUA levels also correlate with the incidence of urological cancers. It was found that gout patients had a higher risk of prostate cancer, followed by bladder and renal cancers . A Swedish study of males with metabolic syndrome showed that high SUA levels were an independent significant predictor of prostate cancer . Drugs can lower blood levels of uric acid by decreasing the body’s production of uric acid or increasing the excretion of uric acid in the urine. The lower the blood uric acid level, the faster the deposits will dissolve. As the deposits start to dissolve , crystals can be released and cause mobilization flares.

Search Health Library

Dr. Obermayr's team found that with increasing uric acid groups, glomerular filtration rates decreased. The odds of developing kidney disease among volunteers in the elevated uric acid group were 1.63 times greater than that of individuals in the low uric acid group. Any abrupt change in the serum uric acid concentration may provoke an acute attack of gouty arthritis. Fluctuations in the serum acid concentration may occur in persons who are fasting, who consume binge amounts of alcohol or who ingest large amounts of protein and purine-rich foods (e.g., bacon, salmon, sweetbreads, scallops, turkey). Obesity in children and adolescents is the global problem seen in both developed and developing countries .

What drugs raise uric acid?

Diuretics are one of the most important causes of secondary hyperuricaemia. The use of loop diuretics, thiazide diuretics and thiazide-like diuretics was associated with an increased risk of incident gout [5, 6].

Elevated serum uric acid also occurs with chronic renal disease, hypertension, hyperlipidemia, diabetes mellitus, obesity, atherosclerosis, and eclampsia. Diseases associated with increased cell turnover such as leukemia, lymphoma, and psoriasis may produce hyperuricemia. Chemotherapy and radiation therapy may cause the release of large amounts of uric acid from necrotic tumor cells. Certain medications reduce the excretion of uric acid including thiazide diuretics, loop diuretics, low dose aspirin, cyclosporine, niacin, ethambutol, pyrazinamide, and didanosine. The Vienna Health Screening Project is an ongoing study including new participants continuously.

Baseline Characteristics And Hyperuricemia

With regard to plasma uric acid levels, purines also contribute to an increase in plasma uric acid in beer drinkers. Further, dehydration and alcoholic ketoacidosis lead to increases in serum uric acid levels. By accelerating adenine nucleotide breakdown and possibly weakly inhibiting xanthine dehydrogenase activity, ethanol also raises plasma concentrations and urinary excretion of hypoxanthine and xanthine. Approximately 80% of patients with elevated serum triglyceride levels also have increased serum uric acid levels. Various ethnic groups, such as Pima Indians, Blackfoot Indians, New Zealand Maoris, and Filipinos, have increased serum uric acid levels.

Learn more about living well with rheumatic disease as well as rheumatologists and the role they play in health care. Your lab report should show the range that your lab uses for each test. Your doctor will also look at your results based on your age, health, and other factors.

Furthermore, Feig et al. demonstrated a reduction of blood pressure in a randomized, double-blind, placebo-controlled, crossover trial in adolescents with newly diagnosed hypertension. To our knowledge, however, there are no such trials yet in youth-onset T2D. In adults with T1D, SUA lowering with febuxostat modestly lowered blood pressure without impacting the RAAS, suggesting that elevated SUA may augment other hemodynamic or inflammatory mechanisms . Results from the Preventing Early Renal Function Loss allopurinol study, an ongoing multicenter randomized clinical trial in adults with T1D, are pending . It is also important to emphasize that in contrast to youth and adults with T2D, people with T1D tend to have lower SUA concentrations due to the uricosuric effect .

This suggests that the protective effect of uric acid may be strongly exerted in elderly women who have decreased female hormone levels. Purines, compounds that are vital components of nucleic acids and coenzymes, may be synthesized in the body or they may be obtained by ingesting foods rich in nucleic material . Approximately 75% of the uric acid excreted is lost in the urine; most of the remainder is secreted into the gastrointestinal tract where it is degraded to allantoin and other compounds by bacterial enzymes. If a blood sample is collected and held at room temperature for one hour before testing, uric acid is decreased by 20%. If a patient is receiving rasburicase, blood samples for measurement of uric acid should be collected in pre-chilled heparinized tubes and immediately placed in ice for transportation to the laboratory.

High uric acid levels in the body can cause crystals of uric acid to form, leading to gout. Some food and drinks that are high in purines can increase the level of uric acid. The progression of cancer and metastasis to the liver during hyperuricemia conditions. During hyperuricemia, the main forms of uric acid are soluble uric acid and monosodium urate crystals. NLRP3 inflammasomes then promote cleavage of IL-1β into its active form, thus producing the IL-1β proinflammatory cytokine. Depending on the presence of MSU, sUA also participates in this process.

The National Institute of Diabetes and Digestive and Kidney Diseases had no role in study design, collection, analysis, interpretation of data, or writing the report. Once overt DKD and CVD manifest, progression can often be postponed, but rarely prevented, by current strategies for glycemic, blood pressure, and lipid control . Accordingly, alternative therapeutic targets are needed to supplement traditional treatments in preventing the development and progression of DKD and CVD in youth-onset T2D.

Chronic Kidney Disease

Epidemiological analyses targeting people 50 years or older revealed that uric acid levels and FEV1/FVC ratios were high among females with the SLC2A9/GLUT9 T/T genotype--a genotype known to have protective lung function qualities. Structural equation modeling further showed that this genotype is involved in lung function maintenance via elevated uric acid levels. Previous studies reported that female hormone therapy for menopausal women has a positive effect on maintaining lung function. It is therefore suggested that the antioxidative effect of uric acid is particularly important for the protection of lung function in women whose hormones decrease with menopause.