Diabetes Mellitus Is Associated With A Lower Risk Of Gout

Content

• Can A Gout Drug Help Reduce Complications Of Diabetes?
• Health Solutions
• Diabetes Mellitus Is Associated With A Lower Risk Of Gout: A Meta
• This Is Important News Since Type 2 Diabetes And Gout Have Many Risk Factors In Common To Begin With
• 4 Duration Of Allopurinol Use

He states that as sugar has gone up in consumption, so has gout in the western world. So, we’ve established that uric levels can be a trigger for gout if they get too high, and that Type 2 diabetes and gout are intertwined. Next week, we’ll look at what you can do to prevent gout and how to treat it if it does occur.

Can A Gout Drug Help Reduce Complications Of Diabetes?

However, the relationship between blood UA and decreased insulin sensitivity in patients with type 1 diabetes mellitus is weaker than in healthy subjects . In a recent analysis not adjusted for important cardiovascular risk factors such as hypertension and diabetes compared with the U.K. general population, people with gout had a 1.7 times higher risk of incident stroke . The study included only hospitalized patients with a diagnosis of gout, which might represent a sicker patient subgroup.

Health Solutions

But it may help decrease the number of attacks and limit their severity. Some research suggests that drinking coffee in moderation, especially regular caffeinated coffee, may be associated with a reduced risk of gout. Drinking coffee may not be appropriate if you have other medical conditions.

Furthermore, surveillance bias due to disease diagnosis is also a possible explanation for our findings, since people with diabetes or gout may be more likely to see the doctors and get their blood glucose or serum uric acid levels measured. However, this surveillance bias could not explain the opposite direction of the associations between the two diseases. We have also applied the 2-year lag analysis and the results remained unchanged. In addition, the sample size was limited in some subgroups, and future large studies are still needed.

Conditions Related To Gout

But it’s the poor circulation, the most likely reason why the risk of gout is relatively high in people with diabetes. Poor blood circulation means you may experience higher uric acid levels, making the kidneys work slowly and inefficiently in releasing it out to your urine. In addition, your blood may be overly acidic and your pH levels are off balance. Diabetes a disease of high blood sugar is also associated with obesity, hypertension, not enough physical activity and high blood pressure. Gout and diabetes are metabolic disorders and if you have both diseases or either one, strong chances they may have been inherited from your genetic makeup.

There are several possible explanations for the link between gout and diabetes, he noted. "One is that the two conditions share pathogenic factors, primarily associated with the metabolic syndrome. A second is that uric acid levels or other gout features such as inflammation may somehow contribute," he said. A second study, conducted by the same researchers using the same database, showed that over a three-year period men with gout who had uncontrolled uric acid levels had a 40% greater risk of kidney disease compared to men with controlled uric acid levels. Treatment may include medications like allopurinol or febuxostat to control your uric acid levels. This can help prevent future gout attacks and also reduce your risk of developing tophi.

Several previous prospective studies have shown that gout is associated with increased risk of incident diabetes in Caucasians11,12,13. Choi et al.11 reported a RR of 1.34 (95% CI 1.09–1.64) in the Multiple Risk Factor Intervention Trial of 11,351 male participants with a high cardiovascular risk profile. In the two studies with both men and women12,13, a stronger association between gout and incident diabetes was found in women compared to men, although it was significant in both sex. In our study, the association was slightly strong in women compared to that in men (1.15 vs. 0.90), however, neither was significant and the interaction test was not significant either. All three previous studies11,12,13 have adjusted for a number of lifestyle factors and comorbidities, including BMI and hypertension. In our study, the association between gout and incident diabetes disappeared after adjustment for BMI and hypertension, suggesting that these two variables were the major confounding factors in the association.

Drugs in the SGLT2 inhibitor class include canagliflozin , dapagliflozin , and empagliflozin . An attack may come on suddenly, but when a flare up ends the symptoms can disappear for long periods of remission. News-Medical.Net provides this medical information service in accordance with these terms and conditions. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide.

"We come out much more strongly that allopurinol is the most desirable first-line agent to most effectively reduce urate levels," Dr. FitzGerald tells EndocrineWeb. In this week’s Be HEALTHistic Video Extra, Dr. Stephen Sinatra discusses a condition that’s close to his own heart — diabetes and high blood sugar. He explains that in order to keep blood sugar stable, it’s essential to exercise and avoid foods high in sugar and carbs, as they trigger a damaging insulin response.

With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects. Your diet can feel a little limited when you have gout and diabetes, but there are still plenty of delicious foods you can enjoy.