New Insights Into The Epidemiology Of Gout

Content

• What Are Future Possible Treatments Of Gout?
• New Insights Into The Epidemiology Of Gout
• A Concise History Of Gout And Hyperuricemia And Their Treatment
• When Should Someone Seek Medical Care For Gout?
• Gout And Hyperuricemia
• How Common Is It?

Metabolic syndrome, a combination of abdominal obesity, hypertension, insulin resistance, and abnormal lipid levels, occurs in nearly 75% of cases. Other conditions commonly complicated by gout include lead poisoning, kidney failure, hemolytic anemia, psoriasis, solid organ transplants, and myeloproliferative disorders such as polycythemia. A body mass index greater than or equal to 35 increases male risk of gout threefold. Chronic lead exposure and lead-contaminated alcohol are risk factors for gout due to the harmful effect of lead on kidney function. Gout is partly genetic, contributing to about 60% of variability in uric acid level. The SLC2A9, SLC22A12, and ABCG2 genes have been found to be commonly associated with gout and variations in them can approximately double the risk.

How long does it take to trigger gout?

Uric acid is a waste product made by the body when it digests certain foods. When uric acid levels are high, crystals of it can accumulate in your joints. This process triggers swelling, inflammation and intense pain ( 5 ). Gout attacks typically occur at night and last 3–10 days (6).

A new study challenges the perception that gout is the result of gluttony and overindulgence in food and drink. Nearly 70 percent of patients surveyed said gout has a negative impact on their family; 74 percent of caregivers agree. Rheum.TV is an informational platform created to educate patients living with a rheumatic disease. With over 100 disease education videos produced by the team at Johns Hopkins Rheumatology. Other factors such as inherited traits and environmental factors also can play an important role in causing gout.

What Are Future Possible Treatments Of Gout?

We talk about signs of gout and how to get care for gout. In some cases, exposure to lead in the environment can cause gout. MRI also detects early subclinical tophaceous deposits and indicates that urate deposits appear to spread along compartmental and fascial planes as opposed to the traditional view of strict radial growth.

Urate crystals may collect in the urinary tracts of people with gout, causing kidney stones. Some people may never experience gout signs and symptoms again. Medications may help prevent gout attacks in people with recurrent gout. If left untreated, gout can cause erosion and destruction of a joint. Purines are also found in certain foods, including red meat and organ meats, such as liver. Purine-rich seafood includes anchovies, sardines, mussels, scallops, trout and tuna.

New Insights Into The Epidemiology Of Gout

There are a number of measures that can help resolve an attack of gout. See Table 2 for summary of treatment strategies for acute gout. One principle is that treatment for an attack of gout should be instituted quickly, since quick treatment can often be rewarded with a quick improvement. You may not be able to prevent gout, but you may be able to avoid things that trigger symptoms. Taking medicines to lower uric acid can prevent progression of gout.

A Concise History Of Gout And Hyperuricemia And Their Treatment

Urate-lowering treatment is usually recommended after the acute attack has resolved. For years, gout patients were told they had to follow a purine-restricted diet to stave off attacks, but those diets weren't very effective and people had a difficult time sticking to them. Now the easier-said-than-done advice is to lose weight, and also to cut back on alcohol, especially beer.

Kidney

Incidence rate is three adults in 1000; 10% to 20% of adults have hyperuricemia. The information provided is for general informational purposes only and is not intended to be medical advice or a substitute for professional health care. You should consult an appropriate health care professional for your specific needs. Pain with gout often goes away on its own in a few days or a week. But if someone with gout doesn't get care, multiple areas of the body an be affected at the same time.

Certain diseases and conditions increase your risk of gout. These include untreated high blood pressure and chronic conditions such as diabetes, obesity, metabolic syndrome, and heart and kidney diseases. There are many conditions that may cause joint inflammation. Podagra is suspected if risk factors are present, and a person has an acute attack of pain in the joint of the big toe. The most frequent signs of a gout attack are swelling, tenderness, redness, and a sharp pain in your big toe.

These attacks are most common at night when you are sitting still and laying flat on your back. While gout usually manifests in the big toe, you may also experience gout attacks in your foot, ankle, or knees. The attacks can be short or long, anywhere from a few days to weeks and you may not have another attack may for months or years. The treatment of gout includes medications having painkiller and anti-inflammatory effect such as NSAIDs, colchicines, and corticosteroid. In addition, certain medications such as allopurinol and probenecid reduce the level of uric acid in the blood.

For the past years, evidence has shown that there is an association between gout and cardiovascular diseases and that they share possible common pathophysiological pathways. Recent research also indicates that genetics may play a big role in determining who gets gout. Ask your doctor if you have questions about your risk for developing this condition. The material of this web site is provided for informational purposes only.