Gout Drug Could Help Treat Heart Failure

Content

• Gout Tied To Higher Risk Of Heart Disease Mortality
• When Should I Call My Healthcare Provider About Gout Symptoms?
• What Is Chronic Pain?
• How Can An Attack Of Gout Be Treated?
• Inflammatory Bowel Disease
• Gout Drug Repurposed To Fight Heart Disease

In experimental studies, oxidative stress has been shown to induce atrial electric remodelling, thus favouring the re-entry mechanism as well as NO decrease, shortening of action potential plateau duration, increase of the repolarisation velocity and AF. In addition, it is reasonable that other risk factors , vascular abnormalities or LVH associated with UA increase may further promote the development of AF. In the study, from the Hospital General Universitario de Alicante in Spain, researchers examined 247 patients presenting with gout. They evaluated traditional risk factors for heart disease and used common risk prediction tools to stratify the patients according to their cardiovascular risk. Scientists still aren’t sure exactly how gout increases cardiovascular disease risk. Ongoing body-wide inflammation driven by uric acid crystal buildup may damage blood vessels, according to a 2017 update on conditions linked to gout published in BMC Medicine, but it’s likely that several inter-related factors are involved.

Is gout a symptom of diabetes?

Articles On The Link Between Diabetes and Gout
If you have type 2 diabetes, your chances of getting gout are higher. And the same is true in reverse. Gout boosts your chance of diabetes. Gout is a kind of arthritis that causes sudden pain and swelling in your joints.

Similarly, we did not find evidence of effect modification by strata of gender or race/ethnicity . Furthermore, adjustment for diuretic use did not alter the observed associations between uncontrolled BP and additional CVD risk factors . Gout is a common form of inflammatory arthritis that is very painful. There are times when symptoms get worse, known as flares, and times when there are no symptoms, known as remission.

Gout Tied To Higher Risk Of Heart Disease Mortality

Third, not all studies consistently reported the data about NSAID and aspirin use and the cardiovascular level of risk of the included patients, therefore, limiting or metaregression. Fourth, our findings of increasing CV-related death were driven by the large sample size and event rate of the CARES trial . In agreement with previous studies, we found a high prevalence of CVD in patients with gout9,11. In our study, we found an even higher prevalence (47%; 95% CI 44–51%) of CVD in gout patients, compared to the CVD prevalence in patients with gout in other studies (35% and 23%, respectively)9,11.

When Should I Call My Healthcare Provider About Gout Symptoms?

If you have sudden or severe pain in a joint, you should talk to your primary care provider . Your PCP may send you to a rheumatologist, a doctor who specializes in gout and other kinds of arthritis. There is a paucity of controlled trial data relating to the management of gout in patients with comorbidities where the presence of these have influence on the response to therapy, or require modification to achieve a successful outcome for the patient. Since uric acid is filtered through the kidneys, the two diseases are related. Some people with severe chronic gout have only short breaks in between attacks and feel symptoms of gout most of the time. A sensitivity analysis including uncontrolled BP as one of the CVD risk factors did not fundamentally change our findings .

As gout progresses, you may not be able to move your joints normally. The affected joint or joints become swollen, tender, warm and red. Erickson AR, Enzenauer RJ, Nordstrom DM, Merenich JA. The prevalence of hypothyroidism in gout. 9 Details of the project, including the quality of the recorded data and diagnoses and the procedures of classifying and coding, have been described elsewhere.

Vlachopoulos C, Xaplanteris P, Vyssoulis G. Association of serum uric acid level with aortic stiffness and arterial wave reflections in newly diagnosed, never-treated hypertension. The effect of allopurinol and febuxostat were compared in a small number of patients with gout. A more favourable effect of febuxostat on both carotid–femoral pulse wave velocity and oxidative stress was found. Experimental and human studies have demonstrated the role of UA as a pro-oxidant, inducing endothelial dysfunction. This may be improved by the administration of XO inhibitors, while other urate-lowering drugs acting through an uricosuric action are ineffective.

During a maximum follow-up of five years, low-dose colchicine was not associated with any serious adverse effects. Neutropenia and myotoxicity were rare and no more frequent with the drug than with placebo. No unfavourable effects were found to occur with combined statin therapy even at high doses of statins.

Who Is At Risk For Gout?

These results raised the question of an association of serum urate with cardiovascular disease and cardiovascular death probably confounded by other factors in the cardiovascular disease causal pathway . Evidence of an association between serum urate levels and surrogate markers of atherosclerosis, such as the carotid intima-media thickness , is starting to emerge. In a cross-sectional study of 234 healthy postmenopausal women there was a significant association between serum urate and IMT, independent of factors such as blood pressure, serum glucose, serum lipids, creatinine, smoking, and diuretic use . Thirty patients with hypertension and hyperuricemia had their carotid IMT compared with that of 25 patients with hypertension but without hyperuricemia, and compared with 25 aged-matched healthy control individuals .

How Can An Attack Of Gout Be Treated?

What's more, a buildup of uric acid in the body may damage the kidneys over time. Following the treatment plan your doctor has designed for you can help control uric acid levels and prevent these serious kidney complications from occurring. Prednisone in a dose of 35 mg daily for 5 days has subsequently been shown to be as effective as naproxen 500 mg twice daily. Our results are consistent with prior studies demonstrating an association between hyperuricemia or gout and the metabolic syndrome –.

Chart review identified patients who were hospitalized for AHFE with International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code I50, received IV bumetanide, and developed an acute gout flare. Data were analyzed using the chi-square test for categorical variables and the two-sample t-test for continuous variables. Doctors place gout under the umbrella term “arthritis” — a broad range of joint diseases and joint pain. Similarly, gout research is aiming to target both the condition as well as its associated complications4.